You should talk to your healthcare provider about any possible side effects of Depo-Provera®. Most of these side effects are not common. Changes in your menstrual cycle is the most common side effect that women experience. You may experience irregular bleeding or spotting. After a year of use, about 50% of women will stop getting their periods.May 2, 2023 · Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight. Depression or other mood changes. Eyesight changes or loss, bulging eyes, or change in how contact lenses feel. A lump in the breast, breast pain or soreness, or nipple discharge. Flu -like signs. After my very first injection 22 years ago, I have had zero periods and zero breakthrough bleeding. Zero side effects. Nothing. This has been a blessing. I had my last Depo Shot on 1/12/21. My next one is not due until 3/30/21. Today I wake up and have bleeding.People who had severe illness with COVID-19 might experience organ damage affecting the heart, kidneys, skin and brain. Inflammation and problems with the immune system can also happen. It isn't clear how long these effects might last. The effects also could lead to the development of new conditions, such as diabetes or a heart or nervous ...The birth control shot (sometimes called Depo-Provera, the Depo shot, or DMPA) contains the hormone progestin. Progestin stops you from getting pregnant by preventing ovulation. When there’s no egg in the tube, pregnancy can’t happen. It also works by making cervical mucus thicker. When the mucus on the cervix is thicker, the sperm can’t ...Long-term effects of injection Depo-Provera (depo-medroxyprogesterone acetate) on carbohydrate and lipid metabolism were studied in 157 women who were treated continuously for a mean duration of 43.3 months. The patients were matched with 162 controls for race, age, parity and height. Glucose tolerance was impaired with higher intolerance at ... Here are a few potential side effects to be aware of if you use it. 1. You might stop having periods. The most common side effect of the shot is a change in a woman’s bleeding pattern, Jason ...For most people, being on birth control long term is safe. Birth control can lower your risk for some cancers and raise your risk for others. It can cause blood clots, heart attacks, and strokes — but the risks are small. Being on birth control doesn’t make it harder to become pregnant once you stop it. 02:48.Similar side effects of the pill vs. Depo-Provera injection. Both methods can cause tenderness or soreness in the breasts. Other side effects of oral contraceptives and the Depo-Provera shot include headaches and mood changes. Both methods can lead to a decreased interest in sex ( decreased libido) in some women.lightening of normal skin color. pain, redness, or hard skin at the injection site. pitting or depression of the skin at the injection site. red face. reddish purple lines on the arms, face, legs, trunk, or groin. swelling of the stomach area. thinning of the scalp hair. Other side effects not listed may also occur in some patients.Mar 23, 2022 · Other long-term birth control options include the: ... The Depo-Provera shot needs to be administered every three months. The birth control implant works for three years. ... Side effects usually ... A further benefit of depot treatment is the achievement of stable plasma concentrations over long periods, allowing injections to be given every few weeks. However, this also represents a potential disadvantage in that there is a lack of flexibility of administration. Should adverse effects develop, the drug cannot be rapidly withdrawn.Good advice below - re: leaving your ovaries in! I had my one and only grand mal seizure on the day I got my period back - about 6 months after taking my last Depo Provera shot. I only took 2 injections of the drug but stopped it due to concerns about loss of bone density and the strange periods that I was having. Depo-Provera is an injection that prevents pregnancy for 3 months at a time. It contains a synthetic hormone called progestin. The birth control shot works similarly to the pill by preventing ...Jan 2, 2023 · The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. red skin lesions, often with a purple center. red, irritated eyes. sneezing. sore throat. sores, ulcers, or white spots in the mouth or on the lips. tightness in the chest. troubled breathing. unusual tiredness or weakness.Pros No need to take a daily pill. You’ll get a shot once every 12 to 13 weeks. Less opportunity to miss a dose. It’s very common to occasionally miss a daily pill. With a shot, you won’t have...Ibuprofen or estrogen to stop bleeding from the Depot-Provera shot. Most side effects of the birth control shot will fade after the first six months. However, it’s important to talk with your ...For most people, being on birth control long term is safe. Birth control can lower your risk for some cancers and raise your risk for others. It can cause blood clots, heart attacks, and strokes — but the risks are small. Being on birth control doesn’t make it harder to become pregnant once you stop it. 02:48.Apr 25, 2023 · When To See a Healthcare Provider. Signs of pregnancy after Depo-Provera ( medroxyprogesterone ) may include missed period, nausea, breast tenderness, and more. Many people are able to get pregnant around 8 to 10 months after their last Depo-Provera shot. Depo-Provera, an injectable birth control method, is more than 99% effective at preventing ... Jul 1, 2021 · There should be confidence in that." “The long-term side effects of COVID infection are a major concern. Up to 10 percent of people who have COVID experience side effects” such as difficulty thinking, pain, tiredness, loss of taste and depression. “We don’t know why that is, how long these symptoms will last or if there are effective ... Aug 7, 2023 · signs of a blood clot - sudden numbness or weakness, severe headache, chest pain, sudden cough, coughing up blood; problems with vision or speech, swelling or pain in an arm or leg. Common Depo-Provera side effects may include: changes in your menstrual periods; weakness, feeling tired; stomach pain; feeling nervous; Depo-Medrol Side Effects: Common, Severe, Long Term Home Depo-Medrol Side Effects Print Save Depo-Medrol Side Effects Generic name: methylprednisolone Medically reviewed by Drugs.com. Last updated on Dec 7, 2022. Serious side effects Other side effects Professional info FAQThe most common side effects of cortisone shots include: Pain at the injection site. A temporary increase in swelling. Bruising. Temporarily increased blood sugar levels. People with diabetes should check their blood sugar level more often for around five days after a cortisone shot.Methylprednisolone (brand names: Medrol®, Depo-Medrol®, A-Methapred®, Solu-Medrol®) is a glucocorticoid steroid medication used to treat many inflammatory conditions, pets with adrenal gland disease, and pets with immune-mediated diseases. It is similar to but slightly more potent than prednisone / prednisolone. Spotting (light bleeding or brown discharge between periods) Not getting your period at all. About half of people stop getting their period while they’re on the shot (don’t worry, this is totally safe). Other possible side effects include: Nausea. Weight gain. Headaches. Sore breasts. Depression.Depo-Provera use may also delay the return of your fertility. About 50% of women will be able to get pregnant within 10 months after their last Depo-Provera injection, but it can take up to 18 months for fertility to return. Some women report irregular or continuous bleeding when using Depo-Provera along with other unwanted side effects.Jun 22, 2023 · People who had severe illness with COVID-19 might experience organ damage affecting the heart, kidneys, skin and brain. Inflammation and problems with the immune system can also happen. It isn't clear how long these effects might last. The effects also could lead to the development of new conditions, such as diabetes or a heart or nervous ... Jan 15, 2022 · itchiness. flushing (warmth and redness or deepening of color in your skin) A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include: swelling under ... You might notice: Uneven menstrual periods or no periods at all Headaches Nervousness Depression Dizziness Acne Changes in appetite Weight gain Unwanted facial and body hair Hair loss Loss of bone mineral density Belly pain Bloating Breakthrough bleeding Fatigue Less interest in sex Weakness ... Spotting (light bleeding or brown discharge between periods) Not getting your period at all. About half of people stop getting their period while they’re on the shot (don’t worry, this is totally safe). Other possible side effects include: Nausea. Weight gain. Headaches. Sore breasts. Depression.Dec 7, 2022 · pounding in the ears. pressure in the stomach. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. seizures. sensation of spinning. severe or continuing stomach pain. slow growth in children. slow or fast heartbeat. sores, ulcers, or white spots on the lips or tongue or inside the mouth. Nov 5, 2022 · 9 Common Depo-Provera Side Effects Irregular Menstrual Bleeding. Menstrual cycle changes are the most common side effects of the Depo-Provera shot. Many... No Periods. After a few shots, Depo-Provera may stop menstruation altogether in some people. Others may have very light... Anxiety and Mood ... Feb 22, 2022 · They might include: Abdominal pain Bloating Decreased interest in sex Depression Dizziness Headaches Irregular periods and breakthrough bleeding Nervousness Weakness and fatigue Weight gain lightening of normal skin color. pain, redness, or hard skin at the injection site. pitting or depression of the skin at the injection site. red face. reddish purple lines on the arms, face, legs, trunk, or groin. swelling of the stomach area. thinning of the scalp hair. Other side effects not listed may also occur in some patients.Risks. Abdominal pain. Bloating. Decreased interest in sex. Depression. Dizziness. Headaches. Irregular periods and breakthrough bleeding. Nervousness. Weakness and fatigue. Weight gain.Mar 6, 2023 · Lupron is a drug doctors prescribe to treat prostate cancer. It works by reducing testosterone levels in the body, slowing cancer growth. Lupron is the brand name for leuprolide acetate. Lupron ... Testosterone cypionate (Depo-testosterone) is an injectable drug used to treat hypogonadism in males. Learn about side effects, warnings, dosage, and more.Sep 28, 2021 · One major drawback of Depo-Provera is the continuous or irregular bleeding (spotting) that can sometimes occur during the first year. While this typically occurs during the first few months, it can persist for up to a year or longer for some people. Learn more about this side effect and what you can do if it persists. TEK IMAGE / Getty Images. Short-term side effects. Short-term side effects are those that we expect a cat to experience when initially placed on corticosteroids. These side effects depend both on the type of steroid prescribed and on the dosage administered and include: increased thirst and urination. increased hunger. general loss of energy.Mar 17, 2022 · Depo-Provera is an injection that prevents pregnancy for 3 months at a time. It contains a synthetic hormone called progestin. The birth control shot works similarly to the pill by preventing ... altered interest in having sexual intercourse. abnormal bleeding from the uterus. a problem with menstrual periods. dizziness. weight gain. headache. nervousness. reactions at the site of the ...Feb 27, 2010 · SU. suzanne66 7 March 2010. Chemical castration (as it is referred to in males) by using Depo-provera lowers testosterone and reduces sex drive. Males can have sexual intercourse but do not want to. It also discourages sexual fantasies and eradicates sexual obsessions. Mood changes and depression are reported side-effects of depo-provera. A further benefit of depot treatment is the achievement of stable plasma concentrations over long periods, allowing injections to be given every few weeks. However, this also represents a potential disadvantage in that there is a lack of flexibility of administration. Should adverse effects develop, the drug cannot be rapidly withdrawn. Very common (10% or more): Increase weight (up to 37%) Common (1% to 10%): Increased appetite, decreased appetite. Uncommon (0.1% to 1%): Diabetes mellitus exacerbated, hypercalcemia, fluid retention. Frequency not reported: Elevations of serum calcium and potassium levels, exacerbation of diabetes mellitus.Long-term effects of injection Depo-Provera (depo-medroxyprogesterone acetate) on carbohydrate and lipid metabolism were studied in 157 women who were treated continuously for a mean duration of 43.3 months. The patients were matched with 162 controls for race, age, parity and height. Glucose tolerance was impaired with higher intolerance at ... Oct 1, 2022 · Lifestyle Changes. Depo-Provera ( depot medroxyprogesterone acetate , or DMPA) is an effective and relatively easy form of birth control. It does appear to cause weight gain for many women, though. Weight gain is often cited as the reason women stop using the shots. DMPA can change body composition and increase fat mass. itchiness. flushing (warmth and redness or deepening of color in your skin) A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include: swelling under ...Uses. Warnings: This medication may cause serious bone loss which may not return to normal after you stop using it. The risk of bone loss increases with longer use of this medication and smoking ...Satisfaction. I'm a 40 yr. old that has been taking Depo-Provera for about 11 years. I like it all except, that I have to go to the doctor every 3 months and I do have the shakes and anxiety, heart palpitations, etc. BUT I also had anxiety before so not exactly sure if the shot is causing it. Also I do feel tired alot. Good advice below - re: leaving your ovaries in! I had my one and only grand mal seizure on the day I got my period back - about 6 months after taking my last Depo Provera shot. I only took 2 injections of the drug but stopped it due to concerns about loss of bone density and the strange periods that I was having. Aug 9, 2023 · Depo-Provera use may also delay the return of your fertility. About 50% of women will be able to get pregnant within 10 months after their last Depo-Provera injection, but it can take up to 18 months for fertility to return. Some women report irregular or continuous bleeding when using Depo-Provera along with other unwanted side effects. A depot injection is a slow-release form of medication. The injection uses a liquid that releases the medication slowly, so it lasts a lot longer. Depot injections can be used for various types of drug, including some antipsychotics. The medication used in depot injections is the same as other forms of the drug, such as tablets or liquid.To go off of this form of birth control, just don’t get your next shot. But be aware that your periods and fertility may take more than the initial three months to return. “In some people, it ...Depo Medrol 80 MG Injection is used for treating Gout which is a type of joint inflammation. Sudden pain at night time and redness of the joints are few symptoms of Gout. Psoriasis. Depo Medrol 80 MG Injection is used to cure Psoriasis which is a type of skin disease. Itchy or sore patches and red skin are few symptoms of Psoriasis. After my very first injection 22 years ago, I have had zero periods and zero breakthrough bleeding. Zero side effects. Nothing. This has been a blessing. I had my last Depo Shot on 1/12/21. My next one is not due until 3/30/21. Today I wake up and have bleeding.headaches and migraine. hot flashes/night sweats. nausea and vomiting. pain. vaginitis. weight gain. People taking Lupron develop symptoms that are similar to menopause, including hot flashes ...Campbell complains about serious side effects from Depo-Provera herself, so those attracted to her survey undoubtedly tend to have worries about the drug. The number one complaint was weight gain ...Long-term case-controlled surveillance of users of Depo-Provera CI found no overall increased risk of ovarian or liver cancer. 5.4 Ectopic Pregnancy Be alert to the possibility of an ectopic pregnancy among women using Depo-Provera CI who become pregnant or complain of severe abdominal pain.Ibuprofen or estrogen to stop bleeding from the Depot-Provera shot. Most side effects of the birth control shot will fade after the first six months. However, it’s important to talk with your ...Mar 6, 2023 · Lupron is a drug doctors prescribe to treat prostate cancer. It works by reducing testosterone levels in the body, slowing cancer growth. Lupron is the brand name for leuprolide acetate. Lupron ... Mar 6, 2013 · The most common side effects associated with DMPA use are bothersome but benign and typically improve with time or upon discontinuation, including irregular bleeding, weight gain, dizziness, abdominal pain, and anxiety . Occasionally, other side effects do occur and may cause significant distress to the patient. Methylprednisolone (brand names: Medrol®, Depo-Medrol®, A-Methapred®, Solu-Medrol®) is a glucocorticoid steroid medication used to treat many inflammatory conditions, pets with adrenal gland disease, and pets with immune-mediated diseases. It is similar to but slightly more potent than prednisone / prednisolone.Jun 16, 2021 · To go off of this form of birth control, just don’t get your next shot. But be aware that your periods and fertility may take more than the initial three months to return. “In some people, it ... Depo-Provera is an injection that prevents pregnancy for 3 months at a time. It contains a synthetic hormone called progestin. The birth control shot works similarly to the pill by preventing ...Jun 16, 2021 · To go off of this form of birth control, just don’t get your next shot. But be aware that your periods and fertility may take more than the initial three months to return. “In some people, it ... A further benefit of depot treatment is the achievement of stable plasma concentrations over long periods, allowing injections to be given every few weeks. However, this also represents a potential disadvantage in that there is a lack of flexibility of administration. Should adverse effects develop, the drug cannot be rapidly withdrawn.Effects on baby A small amount of the synthetic hormones in contraceptives will enter your milk, there is no evidence that this is dangerous to your baby. Some babies younger than six weeks may have difficulty metabolising the hormones and for this reason it is not recommended to start using a hormonal contraceptive until your baby is older. Objectives Depo-Provera is an injectable contraceptive method containing medroxyprogesterone acetate. It has some adverse effects like changes in menstrual pattern, loss in bone mineral density and risk of weight gain. Therefore, this study is aimed at to investigate the effects of Depo-Provera on body weight and blood pressure among Ethiopian women. Institution based cross-sectional study ...Forty-three subjects (37% of discontinuers) restarted Depo-Provera during the study period, with a mean time to restart of 8.4 months after the last Depo-Provera injection. Side effects were the main reported reason for Depo-Provera discontinuation, primarily menstrual irregularities (26%) and weight gain (18%).Lifestyle Changes. Depo-Provera ( depot medroxyprogesterone acetate , or DMPA) is an effective and relatively easy form of birth control. It does appear to cause weight gain for many women, though. Weight gain is often cited as the reason women stop using the shots. DMPA can change body composition and increase fat mass.The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain.pounding in the ears. pressure in the stomach. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. seizures. sensation of spinning. severe or continuing stomach pain. slow growth in children. slow or fast heartbeat. sores, ulcers, or white spots on the lips or tongue or inside the mouth.lightening of normal skin color. pain, redness, or hard skin at the injection site. pitting or depression of the skin at the injection site. red face. reddish purple lines on the arms, face, legs, trunk, or groin. swelling of the stomach area. thinning of the scalp hair. Other side effects not listed may also occur in some patients.some people may put on weight when they use Depo-Provera or Sayana Press contraceptive injections; you may experience side effects like headaches, acne, hair loss, decreased sex drive and mood swings; any side effects can continue for as long as the injection lasts (8 or 13 weeks) and for some time after; RisksMar 5, 2023 · Very common (10% or more): Increase weight (up to 37%) Common (1% to 10%): Increased appetite, decreased appetite. Uncommon (0.1% to 1%): Diabetes mellitus exacerbated, hypercalcemia, fluid retention. Frequency not reported: Elevations of serum calcium and potassium levels, exacerbation of diabetes mellitus. The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain.Depo Provera (Depo medroxyprogesterone Acetate or DMPA) is a long acting progestin given by intramuscular injection every 12 weeks. It has been approved for contraception in the USA since 1992, but has been available in some countries since the 1960s. It is important to understand the benefits, risks and side effects, and to considerPurpose and method: Our objective is to evaluate the effects of the long-term use of depot medroxyprogesterone acetate (DMPA) as a method of contraception on bone mineral density (BMD) and bone remodeling. Forty women (21-44 years old) who used DMPA for contraception for <1, 1-2 and >5 years, in addition to 20 age-matched healthy women ...There should be confidence in that." “The long-term side effects of COVID infection are a major concern. Up to 10 percent of people who have COVID experience side effects” such as difficulty thinking, pain, tiredness, loss of taste and depression. “We don’t know why that is, how long these symptoms will last or if there are effective ...DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL, 40 mg/mL, 80 mg/mL. Sodium Chloride was added to adjust tonicity. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.Mar 17, 2022 · Depo-Provera is an injection that prevents pregnancy for 3 months at a time. It contains a synthetic hormone called progestin. The birth control shot works similarly to the pill by preventing ... Rated Depo-Provera for Endometriosis Report . I was always happy and outgoing. Always with friends or making new friends to hang with. After almost 2 years on this drug I am: • Severely depressed • crazy anxiety • antisocial ( I try but I don’t ever want to be with people or do anything the more I get this shot ) • I don’t feel attracted to anyone • I cry everyday at least 5 ...Short-term side effects. Short-term side effects are those that we expect a cat to experience when initially placed on corticosteroids. These side effects depend both on the type of steroid prescribed and on the dosage administered and include: increased thirst and urination. increased hunger. general loss of energy. The birth control shot (sometimes called Depo-Provera, the Depo shot, or DMPA) contains the hormone progestin. Progestin stops you from getting pregnant by preventing ovulation. When there’s no egg in the tube, pregnancy can’t happen. It also works by making cervical mucus thicker. When the mucus on the cervix is thicker, the sperm can’t ... Mar 6, 2023 · Lupron is a drug doctors prescribe to treat prostate cancer. It works by reducing testosterone levels in the body, slowing cancer growth. Lupron is the brand name for leuprolide acetate. Lupron ... Here are a few potential side effects to be aware of if you use it. 1. You might stop having periods. The most common side effect of the shot is a change in a woman’s bleeding pattern, Jason ...Jan 2, 2023 · The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain. Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight. Eyesight changes or loss, bulging eyes, or change in how contact lenses feel. A lump in the breast, breast pain or soreness, or nipple discharge. Vaginal itching or discharge.Depo-Provera Vial Contraceptives. - Uses, Side Effects, This medication may cause serious bone loss which may not return to normal after you stop using it. The risk of bone loss increases with ...
Depo Medrol 80 MG Injection is used for treating Gout which is a type of joint inflammation. Sudden pain at night time and redness of the joints are few symptoms of Gout. Psoriasis. Depo Medrol 80 MG Injection is used to cure Psoriasis which is a type of skin disease. Itchy or sore patches and red skin are few symptoms of Psoriasis.. Seattle seahawks depth chart
pounding in the ears. pressure in the stomach. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. seizures. sensation of spinning. severe or continuing stomach pain. slow growth in children. slow or fast heartbeat. sores, ulcers, or white spots on the lips or tongue or inside the mouth.Mar 5, 2023 · severe, sudden headache. shortness of breath. slurred speech. stopping of menstrual bleeding. sudden loss of coordination. sudden, severe weakness or numbness in the arm or leg. sudden, unexplained shortness of breath. swelling of the fingers, hands, feet, or lower legs. troubled breathing at rest. Depo Provera (Depo medroxyprogesterone Acetate or DMPA) is a long acting progestin given by intramuscular injection every 12 weeks. It has been approved for contraception in the USA since 1992, but has been available in some countries since the 1960s. It is important to understand the benefits, risks and side effects, and to consider After my very first injection 22 years ago, I have had zero periods and zero breakthrough bleeding. Zero side effects. Nothing. This has been a blessing. I had my last Depo Shot on 1/12/21. My next one is not due until 3/30/21. Today I wake up and have bleeding.Medroxyprogesterone acetate. Medroxyprogesterone acetate ( MPA ), also known as depot medroxyprogesterone acetate ( DMPA) in injectable form and sold under the brand name Depo-Provera among others, is a hormonal medication of the progestin type. [9] [3] It is used as a method of birth control and as a part of menopausal hormone therapy. Allergy shots are a form of treatment called immunotherapy. Each allergy shot contains a tiny amount of the specific substance or substances that trigger your allergic reactions. These are called allergens. Allergy shots contain just enough allergens to stimulate your immune system — but not enough to cause a full-blown allergic reaction.Common side effects may include: weight gain (especially in your face or your upper back and torso); slow wound healing; muscle pain or weakness; thinning skin, increased sweating; stomach ...Long-term case-controlled surveillance of users of Depo-Provera CI found no overall increased risk of ovarian or liver cancer. 5.4 Ectopic Pregnancy Be alert to the possibility of an ectopic pregnancy among women using Depo-Provera CI who become pregnant or complain of severe abdominal pain.The most common side effects associated with DMPA use are bothersome but benign and typically improve with time or upon discontinuation, including irregular bleeding, weight gain, dizziness, abdominal pain, and anxiety . Occasionally, other side effects do occur and may cause significant distress to the patient.One major drawback of Depo-Provera is the continuous or irregular bleeding (spotting) that can sometimes occur during the first year. While this typically occurs during the first few months, it can persist for up to a year or longer for some people. Learn more about this side effect and what you can do if it persists. TEK IMAGE / Getty Images.One major drawback of Depo-Provera is the continuous or irregular bleeding (spotting) that can sometimes occur during the first year. While this typically occurs during the first few months, it can persist for up to a year or longer for some people. Learn more about this side effect and what you can do if it persists. TEK IMAGE / Getty Images.DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL, 40 mg/mL, 80 mg/mL. Sodium Chloride was added to adjust tonicity. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.altered interest in having sexual intercourse. abnormal bleeding from the uterus. a problem with menstrual periods. dizziness. weight gain. headache. nervousness. reactions at the site of the ....